Chromatography

SciCord ELN provides a platform for integrating with Chromatography data systems. The Chromatography solution supports comprehensive documentation of your chromatography experiment:

• Preparation of samples and standard.
• Documenting instrumentation, columns, and methodology.
• Generation of suitability information.
• Calculation of final results.
• Formatted report.
• Visualization of chromatography

One of the benefits of SciCord is the ability to interface your  Chromatography System with sample preparation, standards, instrumentation, columns, and methodology documented within ELN.  A linkage is created between a Chromatography Sequence and the associated ELN documentation.

Calculations may be performed either in the Chromatography System, within ELN or both, depending on the situation.  ELN provides a sophisticated calculation engine for performing validated calculations such as advanced suitability or applying complex assay/impurity methodologies.  The consolidated results of a chromatography analysis are displayed in a formatted report.

The following CDS systems are currently supported (additional systems can be interfaced if needed)

• Empower®
• Agilent®

Visualization of chromatograms by supervisors, quality teams, and auditors is a challenge facing many organizations.  Few of these folks have the access and/or training to view chromatograms in the CDS system.  Static chromatogram images are often recorded in the notebook as a poor substitute.

SciCord ELN provides an easy to use vendor agnostic sequence viewer for reviewers, quality assurance staff, and auditors.  When viewing a notebook, just click on the chromatography link to open the data in SciChrom Viewer, a full-featured, web based viewer.

No training or specific access grants required. Reduce the number of third party Chromatography system licenses in your organization.

A simple, demo version of SciCord’s SciChrom Viewer is accessible below. A guide is also available if you need more information about how SciChrom Viewer works.
[popup_button][popup_button_number]1[/popup_button_number][FA_icon]fas fa-book-reader[/FA_icon] Quick Guide[/popup_button] [popup][popup_number]1[/popup_number]

Zoom/Pan Controls

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• The chart can be panned by left-clicking and holding anywhere in the chart and moving the mouse.
• The chart can be zoomed by scrolling up or down on the scrollwheel, or by using a pinch to zoom gesture on touchscreens.
• Ctrl-Clicking and dragging the mouse (or clicking down on the scrollwheel/middle mouse button and dragging) will create a zoom-box that will define the new pan and zoom of the chart.
  • If the zoom-box does not match the aspect-ratio of the original chart, the injection lines will be vertically stretched to fill the space. This can be used to enlarge small peaks.

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Ctrl-Click or Middle-Mouse click to use the zoom-box

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Options Panel

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The options panel can be accessed by moving the mouse over the gear icon in the top right corner of the chart, or by right-clicking anywhere in the chart.

• Reset Chart: redraws the chart from scratch, restores zoom and panning to default positions
• Reset Focus: Resets the vertical scaling if the chart has been vertically stretched
• Hide/Show Crosshairs: Hides or shows the crosshairs, button label changes contextually
• Show/Hide Retention Time: Shows or hides the retention times on peak labels. The button label changes contextually
• Configure Columns: Shows a popup dialog that allows you to select the visible columns in the peak table and set number of decimals
• Screenshot: launches the screenshot dialog
• Hide/Show All: Hides/Shows all secondary injections. Button label changes contextually.
• Stacked/Normal View: Toggles the Stacked view on and off. Button label changes contextually.
  • If the button is grey and says “Normal View”, secondary injections will be drawn on top of the main injection
  • If the button is blue and says “Stacked View”, the secondary injections are given an offset to separate them out from the main injection and each other
    • Four arrows are available below the button to change this offset by moving the secondary injections up, down, left, or right.

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Legend

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If there are one or more secondary injections, an additional column will be added to the legend called “Main”.

• The circle icon to the left of the name of each secondary injection will be a colored check-mark. Clicking this icon will turn it into a grey X and hide the corresponding injection in the chart. All of the secondary injections can also be hidden/shown at once using the Hide/Show All button in the options panel.
• The circle icon to the right of the name of each secondary injection will be a grey X. Clicking this icon will turn it into a red check-mark and will display the baselines on the corresponding injection.
• The main injection will have a blue circle in the “Main” column, while the secondary injections will have a grey X. Clicking one of the grey Xs will make the corresponding injection the main injection and re-order the chart accordingly.

The legend can be moved around the chart by clicking and dragging it.

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Peak Information

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• Clicking on a peak will highlight the peak in the chart.
  • A mini-table will also appear with relevant information about the peak.
• The full table is located below the chart. Each row corresponds to a peak.
  • Clicking a row will also highlight the peak in the chart.
  • The visible columns can be configured in the options panel.

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For a deeper dive into using SciChrom Viewer, the full user guide can be downloaded:
[FA_icon]fas fa-file-pdf[/FA_icon] Full User Guide

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